The University College of Science, Saifabad, a Constituent College of Osmania University, is situated at Masabtank in Hyderabad. It was established in 1951 in the prime locality at the foot hills of Banjara Hills. Originally the college offered only intermediate courses and was situated at Gulbarga of erstwhile Nizam state. Subsequently it was shifted to the present location. Late Nawab Ali Yavar Jung Bahadur, the then Vice-Chancellor of Osmania University, used his benevolent offices to acquire the present College campus at Saifabad (in the western part of Hyderabad) from the former Government of Hyderabad.

The serene and sprawling campus which spreads over a vast stretch of land measuring about 18.173 acres with lush gardens is in complete contrast to the choas of trafic prevailing outside the college . A fossil confier wood of Araucarioxylon Species of early jurrasic age(175 million years old) which was gifted to the college by the Geological Survey of india(Southern Region, Hyderabad). warmly welcomes any enthusiastic visitor to the college.

The University has taken special interest in giving a face-lift to the entire campus, and in protecting the valuable open sports field. A new library building was constructed in 2003 and efforts for additional space in first floor are under way. A new building for Chemistry, Physics, Mathematics and Biotechnology has been constructed during the period from 2003 to 2005 under two phases. This new P.G. Block caters to the needs of the said departments and provides a modern Seminar Hall with a capacity of 120 seats.

For the past 5 decades, the College has shown steady progress, as enumerated below for the cause of higher education as per the contemporary needs of the students.